Treatment Resistance Disorder (TRD)
Months or even years can go by without any relief. And after the effort it took to get help, it can be demoralizing when you’re just not getting better.
Dr. Debra Fulghum Bruce
The Condition:
- Onset of depression when a patient has not responded to consecutive treatments, with two or more products of different pharmacological classes, used over a sufficient length of time at adequate does, but failed to produce the desired clinical outcome.
- This could disrupt sleep, produce feelings of in adequacy, and may lead to suicidal thoughts.
- Sometimes referred to clinical or unipolar depression, evidenced by distinct lows and or negative emotions.
References
- http://www.pharmafile.com/news/522426/janssens-argues-cost-effectiveness-spravato-treatment-resistant-depression
- https://www.psychiatrist.com/jcp/depression/prevalence-national-burden-treatment-resistant-depression-major-depressive-disorder-in-us/
- https://www.jmcp.org/doi/pdf/10.18553/jmcp.2019.25.7.823
- https://www.sciencedirect.com/science/article/pii/S0165032721008417
- https://home.kpmg/sg/en/home/insights/2021/03/the-rising-social-and-economic-cost-of-major-depression-in-the-asia-pacific.html
- https://academic.oup.com/ijnp/article/22/2/85/5046537
- https://www.jnj.com/health-and-wellness/4-facts-about-treatment-resistant-depression